Aplicación de la inteligencia artificial en la predicción de complicaciones en pacientes con Malaria

Contenido principal del artículo

Eduardo Tuta-Quintero
Daniel Botero-Rosas
Alirio Bastidas-Goyes
Juan Leon-Ariza
Angela Guerrero
Mauricio Agudelo
Natalia Valenzuela

Resumen

Introducción: Este estudio tiene como objetivo desarrollar una red neural (RN) que pueda servir como una herramienta útil para el diagnóstico temprano de la malaria complicada. Materiales y métodos: En este estudio, se desarrolló una red neural feedforward, incorporando 10 variables clínicas en los nodos de entrada, la capa oculta y el nodo de salida. Se aplicaron diversas técnicas de validación como V cross, V cross Aleatorio, Retención Modificada y Muestra Proporcional de Porcentaje para entrenar y validar la red utilizando datos de 412 pacientes.  Resultados: Las variables incluidas en el análisis fueron la presión arterial media, hemoglobina, recuento de leucocitos, recuento de plaquetas, bilirrubina total, presencia de disnea, vómitos, historial previo de malaria, uso previo de medicamentos para la malaria y fiebre persistente. Se utilizaron las técnicas de V cross, Validación Cruzada Aleatoria, Validación de Retención Modificada y Validación de Muestra Proporcional de Porcentaje para evaluar el rendimiento de una RN en el diagnóstico de la malaria. Los valores de sensibilidad variaron del 13% al 47%, con valores predictivos positivos que oscilaron entre el 37% y el 88%. La especificidad se mantuvo consistentemente alta, variando del 79% al 90%. Discusión: La sensibilidad, la especificidad y los valores predictivos positivos variaron según las técnicas: la validación cruzada en V y la validación cruzada aleatoria en V mostraron rangos de sensibilidad más estrechos con fuertes especificidades, mientras que la validación con retención modificada exhibió una mayor variabilidad en la sensibilidad.

Detalles del artículo

Sección
Articulos Originales

Citas

Sagaki P, Thanachartwet V, Desakorn V, Sahassananda D, Chamnanchanunt S, Chierakul W, Pitisuttithum P, Ruangkanchanasetr P. Clinical factors for severity of Plasmodium falciparum malaria in hospitalized adults in Thailand. PLoS One. 2013 ;8(8):e71503. https://doi.org/10.1371/journal.pone.0071503

Rahimi BA, Thakkinstian A, White NJ, Sirivichayakul C, Dondorp AM, Chokejindachai W. Severe vivax malaria: a systematic review and meta-analysis of clinical studies since 1900. Malar J. 2014 ;13:481. https://doi.org/10.1186/1475-2875-13-481

Botwe AK, Oppong FB, Gyaase S, Owusu-Agyei S, Asghar M, Asante KP, Farnert A, Osier F. Determinants of the varied profiles of Plasmodium falciparum infections among infants living in Kintampo, Ghana. Malar J. 2021 ;20(1):240. https://doi.org/10.1186/s12936-021-03752-9

Sutto-Ortiz P, Eleouet JF, Ferron F, Decroly E. Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities. Viruses. 2023 ;15(2):341. https://doi.org/10.3390/v15020341

Carlson CJ, Colwell R, Hossain MS, Rahman MM, Robock A, Ryan SJ, Alam MS, Trisos CH. Solar geoengineering could redistribute malaria risk in developing countries. Nat Commun. 2022 ;13(1):2150. https://doi.org/10.1038/s41467-022-29613-w

Tobón-Castaño A, Giraldo-Castro C, Blair S. Utilidad de los signos clínicos y parasitológicos en el pronóstico de la malaria grave en Colombia. Biomedica. 2012 ;32 Suppl 1:79-94. https://doi.org/10.7705/biomedica.v32i0.613

Tomassi MV, D'Abramo A, Vita S, Corpolongo A, Vulcano A, Ascoli Bartoli T, Bartolini B, Faraglia F, Nicastri E. A case of severe Plasmodium ovale malaria with acute respiratory distress syndrome and splenic infarction in a male traveller presenting in Italy. Malar J. 2024 ;23(1):93. https://doi.org/10.1186/s12936-024-04911-4

Walker IS, Rogerson SJ. Pathogenicity and virulence of malaria: Sticky problems and tricky solutions. Virulence. 2023 ;14(1):2150456. https://doi.org/10.1080/21505594.2022.2150456

Kumar A, Singh PP, Tyagi S, Hari Kishan Raju K, Sahu SS, Rahi M. Vivax malaria: a possible stumbling block for malaria elimination in India. Front Public Health. 2024 ;11:1228217. https://doi.org/10.3389/fpubh.2023.1228217

Murray CJ, Ortblad KF, Guinovart C, Lim SS, Wolock TM, Roberts DA, Dansereau EA, Graetz N, Barber RM, Brown JC, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014 ;384(9947):1005-70. https://doi.org/10.1016/S0140-6736(14)60844-8

Saravu K, Rishikesh K, Kamath A, Shastry AB. Severity in Plasmodium vivax malaria claiming global vigilance and exploration--a tertiary care centre based cohort study. Malar J. 2014 ;13:304. https://doi.org/10.1186/1475-2875-13-304

Manning L, Laman M, Law I, Bona C, Aipit S, Teine D, Warrell J, Rosanas Urgell A, Lin E, Kiniboro B, Vince J, Hwaiwhanje I, Karunajeewa H, Michon P, Siba P, Mueller I, Davis TM. Features and prognosis of severe malaria caused by Plasmodium falciparum, Plasmodium vivax and mixed Plasmodium species in Papua New Guinean children. PLoS One. 2011;6(12):e29203. https://doi.org/10.1371/journal.pone.0029203

Nsanzabana C, Djalle D, Guérin PJ, Ménard D, González IJ. Tools for surveillance of anti-malarial drug resistance: an assessment of the current landscape. Malar J. 2018 ;17(1):75. https://doi.org/10.1186/s12936-018-2185-9

Wongsrichanalai C, Barcus MJ, Muth S, Sutamihardja A, Wernsdorfer WH. A review of malaria diagnostic tools: microscopy and rapid diagnostic test (RDT). Am J Trop Med Hyg. 2007 ;77(6 Suppl):119-27. PMID: 18165483 https://doi.org/10.4269/ajtmh.2007.77.119

Leke RF, Djokam RR, Mbu R, Leke RJ, Fogako J, Megnekou R, Metenou S, Sama G, Zhou Y, Cadigan T, Parra M, Taylor DW. Detection of the Plasmodium falciparum antigen histidine rich protein 2 in blood of pregnant women: implications for diagnosing placental malaria. J Clin Microbiol. 1999 ;37(9):2992-6. https://doi.org/10.1128/JCM.37.9.2992-2996.1999

Chu CS, Stolbrink M, Stolady D, Saito M, Beau C, Choun K, Wah TG, Mu N, Htoo K, Nu B, Keereevijit A, Wiladpaingern J, Carrara V, Phyo AP, Lwin KM, Luxemburger C, Proux S, Charunwatthana P, McGready R, White NJ, Nosten F. Severe Falciparum and Vivax Malaria on the Thailand-Myanmar Border: A Review of 1503 Cases. Clin Infect Dis. 2023 ;77(5):721-728. https://doi.org/10.1093/cid/ciad262

Mello MB, Luz FC, Leal-Santos FA, Alves ER Jr, Gasquez TM, Fontes CJ. Standardization of blood smears prepared in transparent acetate: an alternative method for the microscopic diagnosis of malaria. Malar J. 2014; 13:238. https://doi.org/10.1186/1475-2875-13-238

Hosseini MP, Hosseini A, Ahi K. A Review on Machine Learning for EEG Signal Processing in Bioengineering. IEEE Rev Biomed Eng. 2021;14:204-218. https://doi.org/10.1109/RBME.2020.2969915

Ma G, Chen P, Liu Z, Liu J. The Prediction of Enterprise Stock Change Trend by Deep Neural Network Model. Comput Intell Neurosci. 2022 ;2022:9193055. https://doi.org/10.1155/2022/9193055

Quintero JP, Siqueira AM, Tobón A, Blair S, Moreno A, Arévalo-Herrera M, Lacerda MV, Valencia SH. Malaria-related anaemia: a Latin American perspective. Mem Inst Oswaldo Cruz. 2011 ;106 Suppl 1(Suppl 1):91-104. https://doi.org/10.1590/S0074-02762011000900012

Kuna A, Gajewski M, Szostakowska B, Nahorski WL, Myjak P, Stanczak J. Imported Malaria in the Material of the Institute of Maritime and Tropical Medicine: A Review of 82 Patients in the Years 2002-2014. Biomed Res Int. 2015;2015:941647. https://doi.org/10.1155/2015/941647

Bruneel F, Hocqueloux L, Alberti C, Wolff M, Chevret S, Bédos JP, Durand R, Le Bras J, Régnier B, Vachon F. The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults. Am J Respir Crit Care Med. 2003 ;167(5):684-9. https://doi.org/10.1164/rccm.200206-631OC

Andrade BB, Reis-Filho A, Barros AM, Souza-Neto SM, Nogueira LL,Fukutani KF, Camargo EP, Camargo LM, Barral A, Duarte A, Barral-Netto M. Towards a precise test for malaria diagnosis in the Brazilian Amazon: comparison among field microscopy, a rapid diagnostic test, nested PCR, and a computational expert system based on artificial neural networks. Malar J. 2010 ;9:117. https://doi.org/10.1186/1475-2875-9-117

Mehrtash A, Wells WM, Tempany CM, Abolmaesumi P, Kapur T. Confidence Calibration and Predictive Uncertainty Estimation for Deep Medical Image Segmentation. IEEE Trans Med Imaging. 2020 ;39(12):3868-3878. https://doi.org/10.1109/TMI.2020.3006437

Simundic AM. Measures of diagnostic accuracy: basic definitions. EJIFCC. 2009;19(4):203-211.

Plewes K, Leopold SJ, Kingston HWF, Dondorp AM. Malaria: What's New in the Management of Malaria? Infect Dis Clin North Am. 2019 ;33(1):39-60. https://doi.org/10.1016/j.idc.2018.10.002

Jain V, Basak S, Bhandari S, Bharti PK, Thomas T, Singh MP, Singh N. Burden of complicated malaria in a densely forested Bastar region of Chhattisgarh State (Central India). PLoS One. 2014 ;9(12):e115266. https://doi.org/10.1371/journal.pone.0115266

Troselj-Vukic B, Vuksanovic-Mikulicic S, Sladoje-Martinovic B, Milotic I, Slavuljica I. Unrecognized malaria and its consequences--a case report of severe malaria with acute renal failure. Coll Antropol. 2013 ;37(2):611-3. PMID: 23941012

Tobón-Castaño A, Betancur JE. Severe malaria in pregnant women hospitalized between 2010 and 2014 in the Department of Antioquia (Colombia). Biomedica. 2019 ;39(2):354-369. https://doi.org/10.7705/biomedica.v39i3.4403

Aung NM, Kaung M, Kyi TT, Kyaw MP, Min M, Htet ZW, Anstey NM, Kyi MM, Hanson J. The Safety of a Conservative Fluid Replacement Strategy in Adults Hospitalised with Malaria. PLoS One. 2015 ;10(11):e0143062. https://doi.org/10.1371/journal.pone.0143062

Hendriksen IC, Mtove G, Pedro AJ, Gomes E, Silamut K, Lee SJ, Mwambuli A, Gesase S, Reyburn H, Day NP, White NJ, von Seidlein L, Dondorp AM. Evaluation of a PfHRP2 and a pLDH-based rapid diagnostic test for the diagnosis of severe malaria in 2 populations of African children. Clin Infect Dis. 2011 ;52(9):1100-7. https://doi.org/10.1093/cid/cir143

Artículos más leídos del mismo autor/a